Mix of Gut Microbes “May” Play Role in Crohn’s Disease???

There was a recent article published in Cell, Host and Microbe where researchers took samples of intestinal flora in various parts of the digestive tract in many people with Crohn’s Disease and discovered that there are more “bad” bacteria and less “beneficial” bacteria in the intestinal tracts of those people.  They also stated that the use of antibiotics tends to create this problem and make it worse.

That is EXACTLY what the problem is with a lot of these autoimmune diseases.  Intestinal dysbiosis caused by overuse of antibiotics and exacerbated by poor Western diets.  Leads to inflammation, leaky gut, and possible autoimmune diseases.  There is no “may” to it.  It DOES play a role in Crohn’s disease and many others.

This is also why autoimmune diseases can be reversed!  Heal the gut – heal the disease.  Which is what I did over three years ago.

I will post a link to the NPR article that discussed this research study, and I will also post the medical research paper on my media page so you can read it if you would like.

In some human diseases, the wrong mix of bacteria seems to be the trouble.

http://n.pr/1kmln8f

R.I.P. Harold Ramis

As many of you have probably heard by now, we lost a great comic actor/writer/director today: Harold Ramis. He had been diagnosed with vasculitis only within the past few years, and it was complications from this autoimmune problem which proved to be fatal.

My heart, thoughts and prayers go out to his family in this difficult time.

I just hope this tragedy will create more awareness about autoimmune disease and how functional medicine and more plant-based diets can potentially help people with autoimmune issues.

 

http://movies.yahoo.com/blogs/movie-news/-ghostbusters–actor-harold-ramis-dies-at-69-173530161.html

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Wrong Way

Wrong Way

How people tend to (sadly) respond to the truth about functional medicine and plant-based diets being able to prevent and reverse autoimmune disease, among other health issues.

Chowing Down On Meat, Dairy Alters Gut Bacteria A Lot, And Quickly

This is a GREAT article I found.  It explains just how precarious the good bacteria in our guts are and how quickly they can be overshadowed by bad bacteria.  It is precisely why maintaining a plant-based diet is very important, as well as maintaining healthy intestinal flora by taking great probiotics and even healthy yeast (Saccharomyces boulardii).

by MICHAELEEN DOUCLEFF

December 11, 2013 1:34 PM
To figure out how diet influences the microbiome, scientists put volunteers on two extreme diets: one that included only meat, egg and cheese and one that contained only grains, vegetables and legumes.

To figure out how diet influences the microbiome, scientists put volunteers on two extreme diets: one that included only meat, egg and cheese and one that contained only grains, vegetables and legumes.

Morgan Walker/NPR

Looks like Harvard University scientists have given us another reason to walk past the cheese platter at holiday parties and reach for the carrot sticks instead: Your gut bacteria will thank you.

Switching to a diet packed with meat and cheese — and very few carbohydrates — alters the trillions of microbes living in the gut, scientists report Wednesday in the journal Nature.

The change happens quickly. Within two days, the types of microbes thriving in the gut shuffle around. And there are signs that some of these shifts might not be so good for your gut: One type of bacteria that flourishes under the meat-rich diet has been linked to inflammation and intestinal diseases in mice.

“I mean, I love meat,” says microbiologist Lawrence David, who contributed to the study and is now at Duke University.

“But I will say that I definitely feel a lot more guilty ordering a hamburger … since doing this work,” he says.

While no one's sure which foods are good for our microbiomes, eating more veggies can't hurt.

Scientists are just beginning to learn about how our decisions at the dinner table — or the drive-through — tweak our microbiome, that is, the communities of bacteria living in our bodies. But one thing is becoming clear: The critters hanging out in our intestine influence many aspects of our health, including weight, immunity and perhaps even behavior.

And interest in studying the links between diet and the human microbiome is growing. Previous research in this field had turned up tantalizing evidence that eating fiber can alter the composition of gut bacteria. But these studies had looked at diets over long periods of times — months and even years. David and his colleagues wanted to know whether fiber — or lack of it — could alter gut bacteria more rapidly.

To figure that out, the researchers got nine volunteers to go on two extreme diets for five days each.

The first diet was all about meat and cheese. “Breakfast was eggs and bacon,” David says. “Lunch was ribs and briskets, and then for dinner, it was salami and prosciutto with an assortment of cheeses. The volunteers had pork rinds for snacks.”

Then, after a break, the nine volunteers began a second, fiber-rich diet at the other end of the spectrum: It all came from plants. “Breakfast was granola cereal,” David says. “For lunch, it was jasmine rice, cooked onions, tomatoes, squash, garlic, peas and lentils.” Dinner looked similar, and the volunteers could snack on bananas and mangoes.

“The animal-based diet is admittedly a little extreme,” he says. “But the plant-based diet is one you might find in a developing country.”

David and the team analyzed the volunteers’ microbiomes before, during and after each diet. And the effects of all that meat and cheese were immediately apparent.

“The relative abundance of various bacteria species looked like it shifted within a day after the food hit the gut,” David says. After the volunteers had spent about three days on each diet, the bacteria in the gut even started to change their behavior. “The kind of genes turned on in the microbes changed in both diets,” he says.

In particular, microbes that “love bile” — the Bilophila — started to dominate the volunteers’ guts during the animal-based diet. Bile helps the stomach digest fats. So people make more bile when their diet is rich in meat and dairy fats.

A study last year found that blooms of Bilophila cause inflammation and colitis in mice. “But we didn’t measure levels of inflammation in our subjects,” David says. “That’s the next step.”

Instead, he says, his team’s data support the overall animal model that Bilophila promotes inflammation, which could ultimately be controlled by diet.

“Our study is a proof of concept that you can modify the microbiome through diet.” David says. “But we’re still a long ways off from being able to manipulate the community in any kind of way that an engineer would be pleased about.”

Even just classifying Bilophila as a “bad bacteria” is a tricky matter, says Dr. Purna Kashyab, a gastroenterologist at the Mayo Clinic in Minnesota.

“These bacteria are members of a community that have lived in harmony with us for thousands of years,” says Kashyab, who wasn’t involved in the study. “You can’t just pick out one member of this whole team and say it’s bad. Most bacteria in the gut are here for our benefit, but given the right environment, they can turn on us and cause disease.”

Nevertheless, Kashyab thinks the Nature study is exciting because the findings unlock a potentially new avenue for treating intestinal diseases. “We want to look at diet as a way of treating patients,” Kashyab says. “This study shows that short-term dietary interventions can change microbial composition and function.”

Of course, figuring out exactly how to do that will take much more research.

“The paper has made the next leap in the field,” Kashyab says. “With discovery comes responsible. Once you make this big finding, it needs to be tested appropriately.”